Villin gene promoter sequence and its use in vectors, transformed mammalian cell lines, transgenic animals, and cell lines derived from the animals.

摘要

An isolated DNA sequence encoding a promoter of the human villin gene is provided. The DNA sequence can be operatively linked to a nucleotide sequence of a gene, such as an oncogene, and incorporated in cloning and expression vectors. The vectors are useful in the production of transgenic, non-human mammals as models of colorectal cancer.