PRODUCTION OF NUCLEUS-SUBSTITUTED CHLORINATED TOLUENE

摘要

PURPOSE:To produce the subject compound useful as raw materials for medicines and agricultural chemicals in a high yield in an extremely simple post-treatment operation by chlorinating toluene or monochlorotoluene in liquid phase in the presence of magnesia as a catalyst. CONSTITUTION:Toluene(TOL) or monochlorotoluene(MCT) is chlorinated in liquid phase in the presence of magnesia to produce the subject compound. The magnesia is preferably light calcined magnesia produced by calcining MgCO3 or Mg(OH)2 or heating metallic magnesium in the air. Chlorine is fed into the reaction system at a rate of 0.01-0.1mol/g-cat.hr. TOL or MCT is preferably fed at a rate of 0.05-1mol per 1.0g of the magnesia for batchwise system and at a rate of 0.01 to 0.1mol/g-cat.hr for continuous system. Since the catalyst is not dissolved in the reaction product, the post treatment of the catalyst is simplified.