| 摘要 |
30,163 4,5-DIHYDRO AND 4,5,6,7TETRAHYDROPYRAZOLO¢1,5-A!-PYRIMIDINES Novel compounds having tbe following structural formula: <IMG> Ia or Ib wherein --- may represent the presence of a double bond between the C6 and C7 position, Ia, or the absence of a double bond between the C6 and C7 position, Ib; R1 is selected from the group consisting essentially of hydrogen, bromo, chloro, carbamoyl, carboxyl, carboxyalkoxyl where alkoxyl is (C1-C3), cyano, -CO-CF3, COONa, <IMG> , -CO-C(CH3)3, and <IMG> where X is hydrogen, cyano, halogen and nitro; R2, R4 and R5 may be hydrogen and lower alkyl(C1-C3); R3 is hydrogen, alkyl(C1-C3), <IMG> where R7 and R8 may be the same or different and are selected from the group consisting essentially of hydrogen, halogen, alkyl(C1-C3), nitro, alkoxy(C1-C3), trifluoromethyl, acetylamino or N-alkylacetylamino where alkyl is (C1-C3), and R3 may also be selected from a monovalent radical selected from the class consisting essentially of 3-thienyl, 2-pyridinyl, 3-pyridinyl and 4-pyridinyl, either of said pyridinyl radicals being optionally substituted with an alkyl radical R9, where alkyl is (C1-C4), and the structures of the monovalent 2-pyridinyl, 3-pyridinyl and 4-pyridinyl moieties are depicted respectively as: <IMG> and <IMG> ; R6 is hydrogen or alkyl (C1-C3); pharmaceutical compositions of matter containing the above-defined compounds; methods for using the compounds as anxiolytic agents, antihypertensive agents or antidepressant agent in mammals; processes for the preparation of the compounds.
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