AMYLIN ACTIVITY ASSAYS

摘要

Methods are disclosed for use in identifying or assaying compounds which can inhibit or simulate the ability of amylin to cause hyperlactemia and/or hyperglycemia in in vivo biological models. Methods are also disclosed for use in evaluating the potency of compounds known or suspected to simulate either or both of these actions of amylin. The figure shows the plasma glucose response of rats infused with somatostatin plus amylin (open circle), with a peptide control (open square), or with phentolamine (open triangle).