N-PROTECTED AMINOALKYLALDEHYDES

摘要

A method for synthesizing novel N-protected aminoalkylaldehydes having aldehyde and amino termini and which are useful as crosslinking reagents for preparing conjugates with biologically active compounds is described. N-benzyloxy-carbonylaminoalkylalcohols and N-butyloxy-carbonylaminoalkylalcohols are oxidized with a Dess-Martin periodinane reagent to provide N-protected aminoaldehydes for use as heterobifunctional crosslinking reagents.