| 摘要 |
<p>Apparatus (150) has a housing (153) attached to the skin adhesively and defines a chamber (156) within which suction is applied at a treatment site. After formation of a suction blister the blister is disrupted to expose a dermis layer of skin from which the epithelium has been removed. Liquid drug is then introduced into the chamber for transdermal perfusion directly through the dermis. Suction is applied to the chamber without connection to an external source of suction by means of an evacuated cell (158) separated from the chamber by a disruptable membrane (167). A tubular member (164) is actuated to rupture the membrane, disrupt the blister and deliver liquid to the chamber in successive stages of operation of the apparatus.</p> |
