发明名称 |
THERAPEUTIC APPLICATION OF AN ANTI-INVASIVE COMPOUND |
摘要 |
Tumor invasion and metastasis is the most life threatening aspect of cancer. Invasion and metastasis is a multistep process. Cellular functions required for invasion are attachment, locomotion and directed migration. Regulation of these processes may be independent of cell growth. A carboxylamino-imidazole compound was found to be potent inhibitor of tumor cell attachment, motility, invasion, proliferation, and metastasis. This compound and equivalents thereof constitute a cancer treatment agent of particular use in the treatment of peritoneal carcinomatosis of ovarian cancer.
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申请公布号 |
US5132315(A) |
申请公布日期 |
1992.07.21 |
申请号 |
US19890355744 |
申请日期 |
1989.05.19 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
KOHN, ELISE C.;LIOTTA, LANCE A. |
分类号 |
A61K31/41;A61K31/4192;A61P35/00;A61P43/00;C07D249/04;C07D249/06 |
主分类号 |
A61K31/41 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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