| 摘要 |
<p>NEW MATERIAL:A polypeptide (salt) expressed by the formula {[X] and [Y] are absent or amino acid residue or peptide residue; n is an integer of 2-10}. USE:An adhesion inhibitor, blood platelet agglutination and adhesion inhibitor for animal cells. PREPARATION:For example, Fmoc-amino acids are successively bound from the C-terminal side according to the amino acid sequence of a peptide using a peptide synthesizer and an Fmoc-Pepsyn KHJ resin as a solid-phase support. After introducing the amino acids, the Kaiser test is carried out to conduct reaction while confirming that the reaction proceeds. At the time of introducing Ile, double coupling is performed, since the reaction is insufficient by the coupling at a time. After synthesizing the peptide chain, a crude peptide is liberated from the resin, purified by silica get chromatography and then deprotected to afford the objective polypeptide expressed by the formula.</p> |
