Human bFGF derivatives, their analogs and process for their production.

摘要

Recombinant human basic fibroblast growth factors or functionally equivalent analogs thereof are provided in which at least one of the four cysteine amino acid residues is derivatized. Usually the two cysteines corresponding to those present in positions 69 and 87 of the 146 amino acid form of the natural human basic fibroblast growth factor are derivatized by moieties such as for example -CH2COOH or -CH2CONH2. Such derivatized recombinant human basic fibroblast growth factors may be used for the healing of wounds, ulcers or burns; regeneration of damaged neural tissues; aiding tissue transplant or healing bone graft; or revascularization of ischaemic tissues.