PROCESS FOR PREPARING 3-IODE-2,4,6-TRIMETHYL PHENYL CARBAMOIL METHYL IMINO DIACETIC ACID

摘要

A method for preparing 99mTc-N-(3-iodo-2,4,6-trimethyl phenyl carbamoyl methyl)amino diacetic acid (99mTc-IOTIDA) comprises (a) reacting 2,4,6-trimethyl aniline with chloro acetyl chloride to obtain a cpd. of formula (I), (b) iodinating (I) with I2, (c) reacting the obtd. cpd. with amino diacetic acid of formula HN(CH2COOH)2 to obtain IOTIDA of formula (II), (d) freeze-drying the mixt. of IOTIDA and SnCl2, and (e) reacting it with Na99mTcO4 to obtain 99mTc labeled IOTIDA. 99mTc-IOTIDA is useful for a diagnosis of liver and biliary tract diseases.