发明名称 |
OXIDATION RESISTANT VARIANTS OF PARATHYROID HORMONE |
摘要 |
Described herein are methionine-substituted variants of parathyroid hormone which, relative to their natural counterparts, exhibit reduced sensitivity to oxidation and substantial PTH activity. Their production using recombinant DNA-based techniques is also described, as is their therapeutic use, e.g. in the treatment of osteoporosis. |
申请公布号 |
WO9211286(A1) |
申请公布日期 |
1992.07.09 |
申请号 |
WO1991CA00451 |
申请日期 |
1991.12.18 |
申请人 |
ALLELIX BIOPHARMACEUTICALS INC.;GLAXO CANADA INC. |
发明人 |
BOZATTO, RICHARD, P.;KRONIS, K., ANNE |
分类号 |
C07K14/635;C12N15/16 |
主分类号 |
C07K14/635 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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