发明名称 VACCINES BASED ON HEPATITIS B SURFACE ANTIGEN
摘要 <p>Novel antigen are presented which are useful in vaccine formulations for the prophylactic treatment of a range of infectious diseases. The antigens comprise a hybrid polypeptide, one part being the S antigen of the hepatitis B virus, the other being a heterologous antigen, such as gD from HSV. The two antigens are linked by chemical spacers through a native sulphydryl group present on the surface of the S antigen.</p>
申请公布号 WO1992011291(A1) 申请公布日期 1992.07.09
申请号 EP1991002422 申请日期 1991.12.16
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