摘要 |
The invention relates to novel methylenebisphosphonic acid ester amide derivatives of general formula (I), in which formula W<1>, W<2>, W<3> and W<4> are independently the group OR<1> or the group NR<2>R<3> wherein R<1>, R<2> and R<3> independently are hydrogen or straight or branched, optionally unsaturated C1-C22-alkyl, optionally substituted, optionally unsaturated C3-C10-cycloalkyl, aryl, aralkyl or silyl SiR3, or the groups R<2> and R<3> form together with the adjacent nitrogen atom a 3 to 10-membered saturated, partly saturated or aromatic heterocyclic ring, wherein in addition to the nitrogen atom, there may be one or two heteroatoms from the group N, O and S, provided that in formula (I) at least one of the groups W<1>, W<2>, W<3> and W<4> is hydroxy and at least one of the groups W<1>, W<2>, W<3> and W<4> is the amino group NR<2>R<3>, Q<1> and Q<2> are independently hydrogen, fluorine, chlorine, bromine or iodine, including the stereoisomers, such as the geometrical isomers and the optically active isomers, of the compounds, as well as the pharmacologically acceptable salts of the compounds. |