NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES

摘要

The invention relates to novel methylenebisphosphonic acid ester amide derivatives of general formula (I), in which formula W?1, W2, W3 and W4¿ are independently the group OR1 or the group NR2R3 wherein R?1, R2 and R3¿ independently are hydrogen or straight or branched, optionally unsaturated C¿1?-C22-alkyl, optionally substituted, optionally unsaturated C3-C10-cycloalkyl, aryl, aralkyl or silyl SiR3, or the groups R?2 and R3¿ form together with the adjacent nitrogen atom a 3 to 10-membered saturated, partly saturated or aromatic heterocyclic ring, wherein in addition to the nitrogen atom, there may be one or two heteroatoms from the group N, O and S, provided that in formula (I) at least one of the groups W?1, W2, W3 and W4¿ is hydroxy and at least one of the groups W?1, W2, W3 and W4¿ is the amino group NR?2R3, Q1 and Q2¿ are independently hydrogen, fluorine, chlorine, bromine or iodine, including the stereoisomers, such as the geometrical isomers and the optically active isomers, of the compounds, as well as the pharmacologically acceptable salts of the compounds.