| 摘要 |
The invention relates to penicillins of general formula <FORM:1035462/C2/1> wherein R1 is C1- 4 alkyl, phenyl or phenylalkyl having less than 10 carbon atoms; and R2, R3 and R4 are the same or different and are hydrogen, nitro, amino, C1- 4 alkylamino, C1- 4 dialkylamino, C1- 4 alkanoylamino, C1- 4 alkyl, chlorine, bromine, iodine, C1- 4 alkoxy, hydroxy, sulphamyl, benzyl, cyclohexyl, phenyl or trifluoromethyl, and non-toxic salts thereof. The penicillins are produced by reacting 6-amino-penicillanic acid with an acid chloride, acid bromide, anhydride or mixed anhydride derived from a carboxylic acid of formula <FORM:1035462/C2/2> wherein R1, R2, R3 and R4 have the meaning given above. The salts may be sodium, potassium, calcium, aluminium, ammonium and substituted ammonium, e.g. triethylamine, procaine, dibenzylamine and N,N1-dibenzyl ethylene diamine. A typical compound is a -methyl-thio-o-chloro-cinnamyl penicillin. |
