| 摘要 |
<p>A myocardial imaging agent for use in humans comprising a TC(III) complex ligated in a planar position by a tetradentate ligand having incorporated therein four hard atoms and two furanome rings and in the axial positions by phosphines containing dioxanyl or ether moieties. The agent exhibits improved biodistribution, improved labeling and extremely rapid blood clearance following administration to a human. The agent has high myocardial uptake accompanied with exceptionally rapid hepatobilary clearance and extensive renal clearance to give sufficiently high heart/liver and heart/lung ratio that provide nearly ideal myocardial images in humans.</p> |
