3-Ý2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY¨-1-AZETIDINE CARBOXAMIDES HAVING ANTICONVULSANT ACTIVITY

摘要

The present invention relates to novel 3-(2-chlor-4-trifluoromethylphenoxy)-1-azetidine carboxamides having the formula: wherein R1 and R2, same or different, are selected from hydrogen, C1-C4 alkyl, and allyl. In a series of 3-(substitutedphenoxy)-1-azetidinecarboxamides, introduction of a chlorine atom at the 2-position of the phenoxy group of the corresponding 4-trifluoromethylphenoxy-1-azetidinecarboxamides resulted in unexpected increased potency in anticonvulsant pharmacological tests.