发明名称 |
INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS BY AN ADENO-ASSOCIATED VIRUS GENE FOR HUMAN CELLS |
摘要 |
A recombinant plasmid is disclosed according to the invention which comprises a transcription promoter inducible by gene products expressed by a human lentivirus and a gene which is non-homologous to that human lentivirus. The non-homologous gene encodes a gene product which inhibits lentiviral growth and lentiviral protein production by interfering with the trans-acting gene regulation system of the lentivirus. The expression of the non-homologous gene is further increased by the above-mentioned transcription promoter. The invention further comprises a method of inhibiting lentiviral growth and lentiviral protein production in mammals by transfecting cells of mammals infected with the lentivirus with the above-mentioned recombinant plasmid. The invention further comprises a method of inhibiting lentiviral growth and production by administering to mammals infected with the lentivirus the Rep protein encoded by the above-mentioned non-homologous gene in a pharmaceutically acceptable carrier. |
申请公布号 |
AU1150792(A) |
申请公布日期 |
1992.07.08 |
申请号 |
AU19920011507 |
申请日期 |
1991.12.06 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, |
发明人 |
BARRIE J CARTER;BETH ANN ANTONI;ARNOLD B RABSON;IRVING L MILLER;JAMES P TREMPE;NOR CHEJANOVSKY |
分类号 |
A61K38/00;C07K14/015;C12N15/35 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|