发明名称 DERIVATIVES OF PYRIMIDINYL-PIPERAZINYL-ALKYL AZOLES WITH ANXIOLYTIC AND/OR TRANQUILIZING ACTIVITY
摘要 The present invention relates to heterocyclic compounds characterized in that they correspond to the general formula I: <IMAGE> I in which R1 represents a hydrogen atom or a halogen, n can have the values 1 to 6 and Het represents an azole, or one of its derivatives selected from among imidazole, indazole, tetrahydroindazoles, pyrazole or pyrazoline and which can be represented by the general formula II: <IMAGE> II in which A and B, always different, represent a carbon atom or a nitrogen atom, the dashed line indicates the possible presence of a double bond between positions 4 and 5, and R2, R3 and R4, identical or different, and can also form a part of another ring, aromatic or not, represent a hydrogen atom, a halogen, a lower alkyl radical, a nitro radical, a hydroxyl radical, an oxo radical, an alkoxy radical, a cyano radical, a carboxylic radical, a carboxamido radical, an alkyl carboxylate radical, an aryle or substituted aryl radical, or an amino radical, of general formula III: <IMAGE> III in which R5 and R6, identical or different, represent a hydrogen atom, an alkyl radical, an aryl radical, a heteroaryl radical, an alkenyl radical, an alkylcarboxy radical, an arylcarboxy radical, an alkylsulfonyl radical or an arylsulfonyl radical.
申请公布号 US5128343(A) 申请公布日期 1992.07.07
申请号 US19900476815 申请日期 1990.02.07
申请人 LABORATORIOS DEL DR. ESTEVE 发明人 PINOL, AUGUSTO C.;CONSTANSA, JORDI F.;COROMINAS, JUAN P.
分类号 C07D417/06;A61K31/505;A61P25/00;A61P25/20;C07D403/12;C07D403/14;C07D521/00 主分类号 C07D417/06
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