| 摘要 |
The invention relates to thiazole derivatives with the general formula I <IMAGE> I wherein R1 is halogen, CF3, CN, NO2, OH or C1-C6 alkoxy; R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy, aryl, C6-C13 aralkyl, an unsubstituted amino group, a substituted amino group, or an amino group which is part of a 5- or 6-membered ring; R3 is C1-C6 hydrocarbon, C6-C13 aralkyl, C2-C7 alkoxyalkyl or C1-C13 acyl; and their pharmaceutically acceptable acid addition salts. These new compounds have alpha 2-antagonist activity without dopamine agonist activity and as such are specifically useful for the treatment of depression and other related illnesses, e.g. for treating patients with anxiety disorders and cognitive disturbances.
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