| 摘要 |
The use is disclosed of a family of agents for the manufacture of a medicament for the treatment of anxiety, migraine or cluster headaches. The agents comprise a compound of the formula (I) below or a pharmaceutically acceptable salt thereof. The compound of formula (I) comprises: <CHEM> Z represents the carbon and hydrogen atoms necessary to complete a substituted or unsubstituted, saturated or unsaturated, 5- to 7-membered ring, R<1>, R<2>, and R<3> may be the same or different and comprise hydrogen, lower alkyl, cycloalkyl, lower alkoxy, amino, lower alkyl substituted amino, acylamido, sulfonamido, halogen, or nitro. A represents a moiety selected from formulas (II),(III), (IV), (V), (VI) and (VII). <CHEM> <CHEM> <CHEM> W represents a single bond or the carbon and hydrogen atoms necessary to complete a 3- to 8-membered saturated or unsaturated ring. Y represents a single bond or the carbon and hydrogen atoms necessary to complete a 4 to 8 membered saturated or unsaturated ring. R<6> is selected from hydrogen, lower alkyl, phenyl, phenalkyl, fluorine-substituted alkyl, propargyl, and allyl. R<7> and R<8> may be the same or different and are selected from hydrogen, lower alkyl, and lower hydroxyalkyl. M<1> and M<2> are the same or different and represent hydrogen or methyl. R<1><1> and R<1><2> are the same or different and represent lower alkyl, cycloalkyl, or phenalkyl. n is 0 or an integer of 1 to 3. When Z represents the atoms necessary to complete a 2,3,4,5-tetrahydro-1-benzoxepin ring, R<1> may not equal hydrogen, amino, or alkylamino and R<2> may not equal hydrogen or halogen. When Z represents the atoms necessary to complete a 2,2-dimethyl-2,3-dihydrobenzofuran ring, R<1>, R<2> and R<3> may not simultaneously equal hydrogen and when R<2> is flourine, R<1> and R<3> may not equal hydrogen. When Z represents the atoms necessary to complete a 2,2-dimethyl or a 2,2-diethyl 3,4-dihydrobenzopyran ring, R<2> may not equal fluorine or chlorine when R<1> and R3 are hydrogen. |
