摘要 |
The invention concerns a method of producing cross-linked collagen particles with diameters in the micrometer and nanometer range. A dispersion or solution of collagen in water, with emulsifiers added, is finely mixed with an organic phase, which is not miscible with water, to form a water/organic emulsion. A cross-linking agent is then added and the collagen cross-linked at the droplet boundary surface, the collagen particles thus produced being isolated by separating off the organic phase and washing.
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申请人 |
LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG, 5450 NEUWIED, DE |
发明人 |
KREUTER, JOERG, PROF. DR., 6380 BAD HOMBURG, DE;SCHERER, DIETER, 6454 BRUCHKOEBEL, DE;MUELLER, WALTER, DR.;ROREGER, MICHAEL, 5450 NEUWIED, DE |