发明名称 |
ACID-LABILE LINKER MOLECULES |
摘要 |
. This invention relates to the field of immune therapy of cancer, more specifically to immunoconjugates of a cytotoxic moiety with a targeting moiety, more specifically to immunoconjugates of antibodies or fragments or functional derivatives of antibodies coupled to a cytotoxic substance such as drugs, toxins or radioisotopes. It especially relates to the release of substances bound to a targeting moiety through the use of acid-cleavable linker molecules.
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申请公布号 |
CA2058595(A1) |
申请公布日期 |
1992.07.01 |
申请号 |
CA19912058595 |
申请日期 |
1991.12.30 |
申请人 |
AKZO N.V. |
发明人 |
BOON, PETRUS J.;KASPERSEN, FRANCISCUS M.;BOS, EBO S. |
分类号 |
A61K31/335;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K47/48;A61P35/00;C07D307/34;C07D307/66;C07D493/10;C07D493/20;C07H15/252;C07K1/113;C07K14/435;C07K14/76;C07K16/00;(IPC1-7):C07K17/02;C07H21/00;C07K14/00;C07H19/01;C07D307/60 |
主分类号 |
A61K31/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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