THE PREPARATION OF E-OXIME ETHERS OF PHENYLGLYOXYLIC ESTERS

摘要

A process for preparing an arylglyoxylic of the formula (VIId): Ar-CO-CO-OCH; VIId where Ar is phenyl or naphthyl, each of which can carry from one to four substituents selected from the group compri- sing halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkoxyalkyl, phenyl, phenoxy, benzyloxy, naphthoxy, phenoxyalkyl, benzyloxyalkyl and naphthoxyalkyl, where the last seven substituents can be present only once and can carry from one to three of the following: halogen, alkyl, alkoxy, phenyl, phenoxy, plus as many halogen atoms as there are other carbon atoms which can be substituted, which comprises ay reacting an acyl cyanide of the formula VIb Ar-CO-CN VIb with hydrogen chloride and tert-butyl methyl ether and b) if required, hydrolyzing the byproduct arylglyoxyl- amide of the formula VIIe Ar-CO-CO-NHR VIIe where R is hydrogen or acyl, under acidic conditions in the presence of methanol and c) if required, hydrolyzing the byproduct dimethyl acetal of the arylglyoxylic ester of the formula VIIf