| 摘要 |
Benzylaminoryl-dihydropyridinelactones, process for their preparation, and their use in medicaments A benzylaminoaryl-dihydropyridinelactone compound of the formula (I) (I) in which R1 represents hydrogen, halogen, cyano, nitro, C6-C12-aryl, C1-C8-alkyl, C1-C8-alkoxy, C1C6-alkylthio, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, difluoromethoxy, di-C1-C5-alkylamino, C1-C6-alkoxycarbonyl or C1-C6-alkyl-sulphonyl, R2 represents hydrogen, or represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical having up to 10 carbon atoms which is optionally substituted by C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-alkylsulphonyl, halogen, cyano, hydroxyl, pyridyl, thienyl, pyrimidyl, piperidinyl, phenyl or an amino group, where the amino group carries two identical or different substituents from the series comprising C1-C5-alkyl, phenyl or benzyl, R3 represents C1-C5-alkyl, or represents cyano, hydroxymethyl or formyl, and R4 represents hydrogen, halogen, C1-C5-alkyl or trifluoromethyl, and its isomers, isomeric mixtures, racemates or optical antipodes, and physiologically acceptable salts thereof. The around being useful to improve the contractility of the heart and the tonus of the smooth muscles. Le A 24 962 |
