Novel anti-cholinergic agents contg. quat. ammonium gps. - used to limit side effects of administration of opiate(s) and opioid(s)

摘要

Anticholinergic agents contg. quaternary ammonium gps. are used for prodn. of medicament prepns. for limitation of side effects of opiates/opioids. Analgesic compsns. contg. the anticholinergic agents and an opiate/opiod are also new. The anticholinergic agent is esp. butyl(nor)scopolaminium bromide, N-methyl-scopolaminium bromide, trospium chloride or cimetropium, chloride opiate/opiod is morphine, biprenorphine, hydrocodone or heroin. USE/ADVANTAGE - The anticholinergic agents are used to prevent side effects on the peripheal and central nervous systems and in the gastrointestinal tract leading to colics. Dosage is esp. 15-25 (esp. 20) mg., i.m. or i.v.