| 摘要 |
NEW MATERIAL:An antibiotic saframycin S which is assumed to have structures of immonium and alpha-carbinol as given in formula I or II; the color and description: deep yellow, powder; melting point: 107-115 deg.C; specific rotatory power: alphaD<25>= +32.5 (0.5 MeOH); molecular weight: 553; empirical formula: C28H30N3O8<+>. OH<->. USE:Antibiotic and anticancer agent: it has the same level of biological activity as saframycin A and is effective on gramnegative and -positive bacteria and acid-fast bacteria. Further, it shows effecacy in mice lymphemia, too. PREPARATION:Saframycin A of formula III (R1 is H; R2 is CN) is heated under reflux and agitation to effect acidolysis and denitration, thus giving saframycin S of formula I or II. The compound of formula III is known and obtained by cultivating Streptomyces lavendulae No.314 (FERM-3218). |
