| 摘要 |
Bicyclic and polycyclic amidic derivatives of glumatic, aspartic and 2-amino adipic acids having activities antagonistic to gastrin, of general formula (I) in which r is between 1 and 3 and R1 is selected from mono- and disubstituted phenyl groups, and in which the substituents are selected from chlorine, linear and branched C1-C4 alkyl groups, cyano, nitro, methoxy, and trifluoromethyl groups, and the 2(beta)-naphthyl group, and heterocyclic, monocyclic or bicyclic groups containing one heteroatom such as nitrogen, oxygen or sulphur and selected from furyl, thiophenyl, pirrolyl, pyridinyl, and pyridinyl-N-oxide unsubstituted or mono- or disubstituted with methyl and chlorine, indolyl, thionaphthyl, benzofuranyl, quinolinyl, or isoquinolinyl groups, and in which R2 is selected independently from a heterocyclic spiro group, a bicyclic spiro amino group, a bicyclic amino group (condensed) and an adamantyl alkyl amino group. |
