| 发明名称 |
FUSION POLYPEPTIDES |
| 摘要 |
A non-naturally-occurring fusion protein comprising an extension peptide portion covalently linked at its C-terminus to the N-terminus of a biologically active portion is disclosed. The extension peptide portion can be removed by DPP IV cleavage. A use of fusion proteins with DPP IV cleavable extension peptide portions in medecinal preparations is disclosed. A method of purifying desired proteins from a mixture containing a fusion protein is disclosed. |
| 申请公布号 |
WO9210576(A1) |
申请公布日期 |
1992.06.25 |
| 申请号 |
WO1991US09152 |
申请日期 |
1991.12.12 |
| 申请人 |
THE UPJOHN COMPANY |
发明人 |
KUBIAK, TERESA, M.;SHARMA, SATISH, K. |
| 分类号 |
A61K38/00;A61K38/04;A61K38/22;A61K38/25;A61K38/26;A61K38/27;C07K1/16;C07K14/00;C07K14/485;C07K14/52;C07K14/54;C07K14/55;C07K14/575;C07K14/60;C07K14/605;C07K14/61;C07K14/655;C07K14/665;C07K16/00;C07K19/00;C12N9/22;C12N15/09;C12N15/62;C12P21/02 |
主分类号 |
A61K38/00 |
| 代理机构 |
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| 主权项 |
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