发明名称 |
NOVEL POLYPEPTIDES FOR PROMOTING CELL ATTACHMENT |
摘要 |
Novel polypeptides derived from human fibronectin are described which bind to integrin receptors expressed by cells. The receptor binding site of human fibronectin begins at amino acid residue 1394 and ends at residue 1400 of fibronectin. The polypeptides facilitate attachment of cells to substrates either alone or in conjunction with RGD-containing peptides. Vectors, fusion proteins and antibodies are also described. Methods for promoting cell attachment and for inhibiting cell adhesion are also described. |
申请公布号 |
AU9165991(A) |
申请公布日期 |
1992.06.25 |
申请号 |
AU19910091659 |
申请日期 |
1991.12.03 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
MARK H. GINSBERG;EDWARD F. PLOW;RONALD BOWDITCH |
分类号 |
A61K38/00;A61K39/395;A61L27/00;A61L27/22;C07K14/75;C07K14/78;C07K16/18;C12N5/00;C12N9/12;C12N15/00;C12P21/00;(IPC1-7):A61K37/02;A01N37/18;C07H15/12;C07K7/06;C07K13/00;C07K15/14;C12P21/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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