| 摘要 |
<p>NEW MATERIAL:Compounds of formula I [X is 1-4C alkyl or 1-4C alkoxy; Y is H or 1-4C alkoxy; A is 1-4C alkylene; R is H, 1-4C alkanoyl or (CH2)k-R<1> (R<1> is phenyl, pyridyl, quinolyl, etc.; K is 0 or 1); (m) is 0, 1 or 2; (n) is 0 or 1]. EXAMPLE:N[2-(4-hydroxyphenylthio)acetyl]-2,6-diisopropylaniline. USE:A medicine for arteriosclerosis having inhibitory effectors an acyl-coenzyme A cholesterol acyl-transferase. PREPARATION:An anilide derivative of formula II (Hal is halogen) is made to react with a thiophenol derivative of formula III in the presence of a base (e.g. sodium carbonate) to obtain the objective compound of formula I (in this case n=0).</p> |
