发明名称 |
HEXAPEPTIDES DERIVING FROM AGLUCOTEICOPLANIN AND A PROCESS FOR PREPARING THEM |
摘要 |
Hexapeptides of formula (1) deriving from aglucoteicoplanin and their salts with acids and bases as well as their inner salts, wherein R is hydrogen or a protecting group of the amino moiety. The products of formula (I), wherein R is hydrogen, pos- sess antimicrobial activity in particular against coagulase-negative strains and some S. aureus and S. epidermidis strains which have low sensitivity toward teicoplanin. The hexapeptides are produced by reductive cleavage of aglucoteicoplanin with alkali metal borohydrides in the presence of a hydroalcoholic mixture as solvent.</ SDOAB>
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申请公布号 |
CA2096112(A1) |
申请公布日期 |
1992.06.21 |
申请号 |
CA19912096112 |
申请日期 |
1991.11.21 |
申请人 |
GRUPPO LEPETIT S.P.A. |
发明人 |
MALABARBA, ADRIANO;CIABATTI, ROMEO |
分类号 |
A61K38/00;A61P31/04;C07K1/113;C07K7/06;C07K7/64;C07K9/00;(IPC1-7):C07K7/06;C07K1/14;C07K1/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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