Neuro-protective combination for treating cerebral ischaemia - contains a 5-HT1A receptor agonist and 5-HT2 receptor antagonist

摘要

A combination prepn. consists of (A) an active ingredient with a serotonin agonistic effect, which has a bonding strength on 5-HT 1A receptors smaller than 10000 nmol/l. amd (B) an active ingredient with a serotonin antagonistic effect which has a bonding strength on 5-HT2 receptors smaller than 1000 nmol/l. (A) is Ipsapiron, Gepiron or Buspiron and (B) is ketanserin. Other suitable components B are Pipamperon, Spiperon, Ritanserin or Pirenperin. Wt. ratio A:B is 1:0.01-100. USE/ADVANTAGE - The combination can be used in neuroprotective pharmaceuticals esp. in the treatment of cerebral ischaemia. The neuroprotective effect of (B) is increased synergistically by (A). Suitable daily doses of the combination are 0.01-100 (esp. 1-50) mg/kg