HUMAN ANTI-RH(D) MONOCLONAL ANTIBODIES

摘要

Human Anti-Rh(D) Monoclonal Antibodies The present invention provides human monoclonal antibodies having the following essential characteristics: (a) exhibiting activity against Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system; (b) being IgG3 proteins; (c) having kappa light chains; (d) being of the allotype G3m(21); (e) exhibiting activity against Du cells by an indirect antiglobulin test; (f) exhibiting activity against DIV, DV and DVII variant antigens; and (g) being inactive against DVI or DB variant antigens, which may be employed for Rh-typing of red blood cells and passive immunisation to prevent haemolytic disease of the newborn. Such a monoclonal antibody is exemplified by the monoclonal antibody of cell line ECACC 87091606 deposited at the European Collection of Animal Cell Cultures, Porton Down, U.K. on 16th September 1987.