发明名称 |
Oral once-per-day organic nitrate formulation which does not induce tolerance |
摘要 |
A controlled-release organic nitrate formulation for once-per-day oral administration is provided by spheres having a core which includes an organic nitrate, and a membrane surrounding the core composed of a pharmaceutically acceptable, film forming polymer. The film forming polymer is effective to permit release of the organic nitrate from the spheres, over a daily dosing period, at a rate that achieves a therapeutically effective level of the organic nitrate, while effecting a drug holiday towards a latter portion of the daily dosing period so as not to induce tolerance.
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申请公布号 |
US5122384(A) |
申请公布日期 |
1992.06.16 |
申请号 |
US19890349533 |
申请日期 |
1989.05.05 |
申请人 |
KV PHARMACEUTICAL COMPANY |
发明人 |
PARADISSIS, GEORGE N.;GAREGNANI, JAMES A.;WHALEY, ROY S. |
分类号 |
A61K9/22;A61K9/50;A61K9/52;A61K9/54 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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