HUMAN ANTI-RH(D) MONOCLONAL ANTIBODIES

摘要

Human Anti-Rh(D) Monoclonal Antibodies The present invention provides human monoclonal antibodies having the following essential characteristics: (a) exhibiting activity against Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system; (b) being IgGl proteins; (e) having kappa light chains; (d) being Glm (3) or Glm (1, 17) allotype; (e) exhibiting activity against Du cells by an indirect antiglobulin test; (f) exhibiting activity against DIV, DV and DVII variant antigens; and (g) being inactive against DVI or DB variant antigens, which may be employed for Rh-typing of red blood cells and passive immunisation to prevent haemolytic disease of the newborn. Cell lines capable of producing such monoclonal antibodies were deposited at the European Collection of Animal Cell Cultures, Porton Down, U.K. on 16th September 1987 under accession numbers ECACC 87091605 and ECACC 87091604.