发明名称 |
METHODS AND COMPOSITIONS FOR DETECTING AND QUANTITATING HEMATOPOIETIC TUMORS |
摘要 |
Methods and compositions for the diagnosis and prognosis of hematopoietic tumors, such as T-cell acute lymphoblastic leukemia, in a human. The invention relates to using nucleic acid hybridization probes to detect, by fluorescent in situ chromosome hybridization, deletion of tal-1 locus on chromosome 1 from human cells to confirm T-cell acute lymphoblastic leukemia in the patient. Methods and compositions for monitoring the presence of minimal residual hematopoietic tumor cells, such as T-cell acute lymphoblastic leukemia cells, in remission cells of a patient. The invention relates to using nucleic acid hybridization probes to detect alteration of tal-1 locus on chromosome 1 from a DNA extract to confirm the presence of residual T-cell acute lymphoblastic leukemia cells in the patient. Methods to quantitate the amount of hematopoietic cells are described. Kits for detecting and monitoring hematopoietic tumor cells in a patient are provided. Kits for quantitating hematopoietic tumor cells in a patient in remission are also provided. |
申请公布号 |
WO9209702(A1) |
申请公布日期 |
1992.06.11 |
申请号 |
WO1991US08707 |
申请日期 |
1991.11.21 |
申请人 |
UNIVERSITY OF TEXAS SYSTEM BOARD OF REGENTS |
发明人 |
SMITH, R., GRAHAM;BAER, RICHARD, J. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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