| 摘要 |
Disclosed are methods and products for epitope-directed immunization with a vaccine including an anti-idiotype antibody. The anti-idiotype antibody is conjutated to a carrier. The carrier is a protein against which the vaccine recipient has previously been immunized or otherwise previously exposed, or a peptide segment of such a protein containing determinants recognized by the antigen-specific receptors on the T helper cells, or an antibody which enhances the immune response against the anti-idiotype. The carrier should not alter the conformation of the anti-idiotype after conjugation. The anti-idiotype antibody is preferably one which induces production of neutralizing antibodies against HIV-1, in which case the preferred carrier is HBsAg or HIV-1 p24, or a T helper peptide derived from HBsAg or HIV-1 p24. It is more preferable if the anti-idiotype antibody induces production of neutralizing antibodies against the external envelope glycoprotein gp120 of HIV-1, and it is most preferable if it induces them against the principle neutralizing determinant of gp120. One such exemplary anti-idiotype antibody is AB19-4. |
