BENZOFURAN AND BENZTHIOPHENE DERIVATIVES

摘要

The invention provides compounds of general formula (I) or a physiologically acceptable salt, solvate or metabolically labile ester thereof wherein Q represents an oxygen or sulphur atom; R<1> represents a hydrogen atom or a halogen atom or a group selected from C1-6alkyl, C2-6alkenyl, fluoroC1-6alkyl, -CHO, -CO2H, C1-6alkoxy, or -COR<2>; Ar represents the group (a); R<2> represents a group selected from C1-6alkyl, C2-6alkenyl, C1-6alkoxy or the group -NR<12>R<13>; R<3> represents a group selected from -CO2H, -NHSO2CF3 or a C-linked tetrazolyl group; R<4> and R<5>, which may be the same or different, each independently represent a hydrogen atom or a halogen atom or a C1-6alkyl group; Het represents the group (b); X represents N or CH; Y represents N or CR<7>; Z represents N or CR<7>; R<6> represents a hydrogen atom or a C1-6alkyl, C2-6alkenyl or a C1-6alkylthio group; R<7> represents a halogen atom or a group selected from cyano, nitro, C1-6alkyl, C2-6alkenyl, fluoroC1-6alkyl, -(CH2)mR<8>, -(CH2)nCOR<9>, or -(CH2)pNR<10>COR<11>; R<8> represents a hydroxy or C1-6alkoxy group; R<9> represents a hydrogen atom or a group selected from hydroxy, C1-6alkyl, C1-6alkoxy, phenyl, phenoxy or the group -NR<12>R<13>; R<10> represents a hydrogen atom or a C1-6alkyl group; R<11> represents a hydrogen atom or a group selected from C1-6alkyl, C1-6alkoxy, phenyl, phenoxy or the group -NR<12>R<13>; R<12> and R<13>, which may be the same or different, each independently represent a hydrogen atom or a C1-4alkyl group or -NR<12>R<13> forms a saturated heterocyclic ring which has 5 or 6 ring members and may optionally contain in the ring one oxygen atom; m represents an integer from 1 to 4; n represents zero or an integer from 1 to 4; and p represents an integer from 1 to 4; with the proviso that at least one of X, Y and Z is a nitrogen atom, and with the further proviso that when X is N at least one of Y and Z is N and when Y is N at least one of X and Z is N. The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.