发明名称 |
A process for the preparation of a 3-alkylated indole, intermediates, and a process for the preparation of a derivative thereof. |
摘要 |
A process for the preparation of a 3-alkylated indole, which comprises:- a) reacting a N-(2-nitrostyryl) enamine with an alkylating agent to afford an imine salt, b) optionally reacting the imine salt with water to afford a (2-nitrophenyl)acetaldehyde, and c) reacting the imine salt or the (2-nitrophenyl)acetaldehyde with a reducing agent capable of selectively reducing the nitro group, to afford the desired 3-alkylated indole. a |
申请公布号 |
EP0489547(A1) |
申请公布日期 |
1992.06.10 |
申请号 |
EP19910311072 |
申请日期 |
1991.11.29 |
申请人 |
IMPERIAL CHEMICAL INDUSTRIES PLC |
发明人 |
JACOBS, ROBERT TOMS;COSTELLO, GERARD FRANCIS;BROOK, STEPHEN ALAN;HARRISON, PETER JOHN |
分类号 |
A61K31/40;A61K31/403;A61K31/404;A61P9/00;A61P11/00;A61P17/00;A61P27/02;A61P27/14;A61P37/08;A61P43/00;C07C53/21;C07C53/50;C07C205/58;C07C205/61;C07C211/15;C07D209/08;C07D209/10;C07D209/18;C07D209/24;C07D209/42 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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