ANTICOAGULANT POLYPEPTIDES.

摘要

Recombinant human urinary thrombomodulin and variant polypeptides produced as a result of replacement, deficiency, addition and like operations of amino acids in part of the amino acid sequence of the thrombomodulin, having a capability of binding with thrombin and anticoagulant and thrombolytic activities. They can be produced efficiently in large amounts by the gene recombination techniques, and are useful for preventing and treating diseases which participate in an increase of blood coagulation, because they are free from adverse effects such as induction of hemorrhage.