4-amino-4-ene-steroids and their use as 5 alpha -reductase inhibitors

摘要

The present invention relates to 4-amino- DELTA 4-steroids which are useful as inhibitors of 5 alpha -reductase. The compounds are prepared by the reaction of an appropriate 4-azido steroid with triphenylphosphine in an aqueous inert solvent with heating. The present application is a continuation-in-part of application Ser. No. 561,041, filed Aug. 1, 1990 and application Ser. No. 671,555, filed Mar. 19, 1991.