| 摘要 |
A rapamycin dimer of general formula (1) <IMAGE> (I) <IMAGE> wherein A is -(CH2)n-, -(CH2)n-(CH=CH)-(CH2)m-, -(CH2)n-(-C 3BOND C-)-(CH2)m-, <IMAGE> <IMAGE> substituted alkyl, substituted alkenyl, substituted alkynyl, and substituted aromatic; n=1-10, m=1-10 and n=m or n NOTEQUAL m or a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppressive activity is useful in treating transplantation rejection host vs. graft disease, autoimmune diseases, and diseases of inflammation.
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