| 摘要 |
2094123 9210504 PCTABS00013 Novel acids, esters, and salts of phenyl, naphtyl, quinoxalinyl, and biphenyl bisphosphonic acids and 1,2-oxaphosphepins are described. These compounds are useful as antiinflammatory and anti-arthritic agents. Also described are known compounds of the phenyl, naphthyl, quinoxalinyl, and biphenyl bisphosphonate classes which are also useful as antiinflammatory and anti-arthritic agents. Representative compounds include ¢1,2-phenyldiyl!-bis(methylene)bisphosphonic acid tetramethyl ester, ¢2,3-quinoxalindiyl!bis(methylene)bisphosphonic acid tetramethyl ester, ¢¢3-(propyl)-4-(methoxy)-1,8-naphthalenediyl!bis-(methylene)!bisphosphonic acid tetramethyl ester, ¢2,6-naphthalenediylbis(methylene)bisphosphonic acid tetraethyl ester, and ¢2,2'-biphenylenebis(methyl)!bisphosphonic acid tetramethyl ester. Representative oxaphosphepins include the preferred 3,4-dihydro-3-methoxy-7-(phenylmethoxy)-1H-naphth¢1,8de!¢1,2!oxaphosphepin-3-_ oxide. |
