| 摘要 |
The invention concerns an aryl derivative of the formula I, <CHEM> wherein Ar<1> is optionally substituted phenyl, naphthyl or a heterocyclic moiety, and X<1> is oxy, thio, sulphinyl, sulphonyl, difluoromethylene, imino, (1-4C)alkylimino or optionally substituted (1-4C)alkylene, or X<1> is a group of the formula -X<4>-CR2- or -CR2-X<4>- wherein X<4> is oxy, thio, sulphinyl, sulphonyl or carbonyl and each R is hydrogen, methyl or ethyl; each of Ar<2> and Ar<3> is optionally substituted phenylene; X<2> is oxy, thio, sulphinyl or sulphonyl; R<1> is (1-4C)alkyl; and R<2> and R<3> together form a group of the formula -A<1>-X<3>-A<2>- which together with the carbon atom to which A<1> and A<2> are attached define a ring having 5 to 7 ring atoms, wherein each of A<1> and A<2> is (1-3C)alkylene and X<3> is oxy, thio, sulphinyl or sulphonyl; which compounds are inhibitors of 5-lipoxygenase and are useful in the treatment of inflammatory or allergic disease. |
