| 摘要 |
Procedure for preparing 5 - fluoro - 2 - [[(4 - cyclopropylmethoxy - 2 - pyridinyl)methyl]sulphinyl]1H - benzimidazole. It involves oxidizing 5 - fluoro - 2 - [[(4 - cyclopropylmethoxy - 2 - pyridinyl)methyl] - sulphinyl]1H - benzimidazole using an oxidizing agent, usually in a solvent selected from halogenated hydrocarbons, alcohols, ethers and ketones, and, optionally, converting the compound obtained into a physiologically acceptable salt by reacting it with a base capable of releasing the desired cation, or separating said compound into a pure enantiomer by means of chromatography or fractional crystallization. The resultant product is useful for inhibiting gastric acid secretion and treating inflammatory gastrointestinal diseases in mammals, including man.
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