ANTIBODIES THAT BIND TO A LIGAND-INDUCED BINDING SITE ON INTEGRIN AND INDUCE INTEGRIN ACTIVATION

摘要

An integrin-activating antibody is disclosed that immunoreacts with an integrin and when immunoreacted increases the binding affinity of the integrin for binding to ligands specific for the integrin. The antibody also immunoreacts with a ligand-induced binding site (LIBS) on the integrin when the integrin is specifically bound to its ligand. Further disclosed are therapeutic compositions and methods for promoting cell adhesion using the disclosed integrin-activating antibodies.