COMPOSITIONS FOR REDUCING OXIDATIVE INJURY

摘要

Compositions for reducing oxidative injury to an animal that includes a modified superoxide dismutase, wherein the modification comprises substituting a first amino acid residue located within 3-12 ANGSTROM of the active site of the superoxide dismutase with a second amino acid residue capable of reacting with a highly reactive nitrating species, such as nitronium ion, formed from the reaction of peroxynitrite and superoxide dismutase.