发明名称 |
CONJUGATES OF ANTI-IDIOTYPE ANTIBODIES AND CARRIERS AND THEIR USE IN EPITOPE-DIRECTED IMMUNIZATION |
摘要 |
Disclosed are methods and products for epitope-directed immunization with a vaccine including an anti-idiotype antibody. The anti-idiotype antibody is conjutated to a carrier. The carrier is a protein against which the vaccine recipient has previously been immunized or otherwise previously exposed, or a peptide segment of such a protein containing determinants recognized by the antigen-specific receptors on the T helper cells, or an antibody which enhances the immune response against the anti-idiotype. The carrier should not alter the conformation of the anti-idiotype after conjugation. The anti-idiotype antibody is preferably one which induces production of neutralizing antibodies against HIV-1, in which case the preferred carrier is HBsAg or HIV-1 p24, or a T helper peptide derived from HBsAg or HIV-1 p24. It is more preferable if the anti-idiotype antibody induces production of neutralizing antibodies against the external envelope glycoprotein gp120 of HIV-1, and it is most preferable if it induces them against the principle neutralizing determinant of gp120. One such exemplary anti-idiotype antibody is AB19-4. |
申请公布号 |
WO9208491(A1) |
申请公布日期 |
1992.05.29 |
申请号 |
WO1991US08653 |
申请日期 |
1991.11.19 |
申请人 |
TANOX BIOSYSTEMS, INC. |
发明人 |
CHANG, TSE, WEN;FUNG, MICHAEL, S., C. |
分类号 |
A61K39/00;A61K39/44;C07K16/42 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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