发明名称 |
METHOD OF INHIBITING TRANSFORMATION, GROWTH AND METASTASIS OF CELLS IN WHICH PURINE METABOLIC ENZYME ACTIVITY IS ELEVATED |
摘要 |
A method of inhibiting growth, transformation, and/or metastasis of mammalian cells, particularly epithelial cells, in which activity of at least one enzyme, which participates in purine metabolism or regulation of nucleotide levels or the relative ratios of their phosphorylated states, is elevated. In particular, a method of inhibiting transformation, growth and/or metastasis of mammalian cells in which a DNA tumor virus, a DNA tumor virus factor or other factor which has an equivalent effect on cells has acted. |
申请公布号 |
WO9208456(A2) |
申请公布日期 |
1992.05.29 |
申请号 |
WO1991US08275 |
申请日期 |
1991.11.07 |
申请人 |
AMIRA, INC. |
发明人 |
KADDURAH-DAOUK, RIMA;LILLIE, JAMES, W. |
分类号 |
A61K38/55;A61K31/00;A61K31/19;A61K31/195;A61K31/415;A61K31/505;A61K31/66;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7076;A61K38/00;A61K45/00;A61K48/00;A61P31/00;A61P31/12;A61P35/00;A61P43/00;C07D233/46;C07D233/60;C07D233/88;C07D239/04;C07D239/14;C07D303/36;C07H19/20;C07K14/82;C12N9/12;C12N15/09;C12N15/113;C12N15/54;C12Q1/50;G01N33/573;G01N33/574 |
主分类号 |
A61K38/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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